A Comparison of total phenolic content, free radical scavenging potential and anti-hyperglycemic condition from leaves extract of Moringa stenopetala and Moringa oliefera
Keywords:
Total Phenolic Content, antioxidant, ant-hyperglycemic, Moringa stenopetala, M. olieferaAbstract
Background: In Ethiopia Moringa stenopetala exists in the arid and semi-arid regions in the southern Rift valley and it is widely grown for its edible leaves and used traditionally for treating Diabetes mellitus.
Objective: The purpose of this study was to compare the total phenolic content, DPPH scavenging potential and anti-hyperglycemic effect in diabetic mice form leaves extracts of M. stenopetala and M. oliefera.
Method: Phenolic content in each Moringa sample was measured using the Folin Ciocalteu’s reagent at an absorbance of 752 nm, whereas free radical scavenging potential was measured by in vitro by the DPPH assay. The anti-hyperglycemic effect of Fasting Blood Glucose level was assessed by administration of 300mg/kg of methanol water (80:20) extract and ethyl acetate fraction of the two Moringa leaves in Streptozotocin induced mice.
Results: The ethyl acetate fraction of M. stenopetala showed highest total phenolic content and strong free radical scavenging potential. The ant-hyperglycemic effect result showed that ethyl acetate fraction of M. stenopetala treatment resulted in significant reduction of fasting blood glucose level initially was 190 3.4351 mg/dl and it reduced to 129 1.8708 mg/dl and 109 mg/dl respectively after 14 and 21 days administration.
Conclusion: The results support the widely claimed use of M. stenopetala as potential antioxidant and anti-hyperglycemic effect to treat diabetes mellitus.
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