What can research evidence tell us about Monkeypox Outbreak? Rapid Evidence Review
DOI:
https://doi.org/10.20372/ejphn.V7i2.249Abstract
Key Findings
Monkey pox (MPX) has similar virus family and symptoms with that of smallpox.
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The symptoms of monkeypox includes fever, headache, muscle aches, backache, swollen lymph nodes, chills, exhaustion, rash that occurs on the face, within the mouth, hands, feet, chest, genitals, or anus.
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Males make up of more than half of monkeypox cases in most outbreaks.
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People who had received a smallpox vaccination had a lower overall attack rate than those who didn’t received a smallpox vaccination.
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According to the WHO the case fatality rate (CFR) for monkeypox was 3 – 6% and all deaths were among unvaccinated against smallpox.
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Human to human transmission of monkey pox includes, sharing a room or bed, living in the same house, and drinking or eating from the same dish with infected individual.
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Avoiding coming into close, skin-to-skin contact with the monkey pox infected individual, washing hands frequently or use an alcohol-based hand sanitizer, not handling or touching the bedding, towels, or clothing of a sick person, avoiding contact with rodents, primates and other animals, etc were methods identified for prevention of monkey pox.
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Tecorivimat which is developed for treating orthopoxvirus associated infection may be used for tratment of monkypox virus and vaccination may be considered.
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References
African CDC (2022). Press Release on Monkeypox situation in Africa. Available at: https://africacdc. org/news-item/press-release-on-monkeypox-situation-in-africa/.
Beer EM & Bhargavi RV (2019). A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Neglected Tropical Diseases, 13(10): 1–20. doi: 10.1371/journal.pntd.0007791.
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR & Steffen R (2022). The changing epidemiology of human monkeypox—A potential threat? A systematic review. PLoS Neglected Tropical Diseases, 16(2):1–20.doi:10.1371/journal. pntd.0010141.
CDC (2022a). 2022 Monkeypox Outbreak Global Map. Available at: https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html.
CDC (2022b). 2022 U.S. Monkeypox Outbreak.Available at:https://www.cdc.gov/poxvirus/monkeypox/prevention.html.
CDC (2022c). About Monkeypox. Available at:https://www.cdc.gov/poxvirus/monkeypox/about.html.
CDC (2022d). Considerations for Monkeypox Vaccination. Available at: https://www.cdc.gov/poxvirus/monkeypox/considerations-for-monkeypox-vaccination.html.
Damon IK (2012). Smallpox, Monkeypox, and Other Poxvirus Infections. Twenty Fou, Goldman’s Cecil Medicine: Twenty Fourth Edition. Twenty Fou. Elsevier Inc. doi: 10.1016/B978-1-4377-1604-7.00380-8.
Ethiopian Public Health Institute (EPHI) & PHEOC. (2022). Monkeypox Outbreak Update. Addis Ababa.
Jamieson DJ, Cono J, Richards CL & Treadwell TA (2004). The role of the obstetrician-gynecologist in emerging infectious diseases. Monkeypox and pregnancy. Obstetrics and Gynecology, 103(4): 754–756. doi: 10.1097/01.AOG.0000114987.76424.6d.
Overton ET, Lawrence S, Stapleton J, Weidenthaler H, Schmidt D & Nopora K. et al. (2020). MVA-BN as monkeypo, vaccine for healthy and immunocompromised. International Journal of Infectious Diseases, 101, p. 464. doi: 10.1016/j.ijid.2020.09.1217.
Radonić A, Metzger S, Dabrowski PW, Couacy-Hymann E, Schuenadel L & Kurth A, et al. (2014). Fatal monkeypox in wild-living sooty mangabey, Côte d’Ivoire, 2012. Emerging Infectious Diseases, 20(6): 1009–1011. doi: 10.3201/eid2006.131329.
WHO (2022a). 2022 Monkeypox Outbreak: Global Trends. Available at: https://worldhealthorg.shinyapps.io/mpx_global/.
WHO (2022b). Monkeypox Key Fact sheet. Available at: https://www.who.int/news-room/fact-sheets/detail/monkeypox.WHO (2022c). Monkeypox outbreak toolbox. Available at: https://www.who.int/emergencies/outbreak-toolkit/disease-outbreak-toolboxes/monkeypox-outbreak-toolbox#:~:text=WHO suggested outbreak case definition,or more acute skin lesions.
WHO (2022d). Multi-country monkeypox outbreak: situation update. WHO (2022e). WHO Director-General declares the ongoing monkeypox outbreak a Public Health Emergency of International Concern. Available at: https://www.who.int/europe/news/item/23-07-2022-who-director-general-declares-the-ongoing-monkeypox-outbreak-a-public-health-event-of-international-concern.
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